Publications

  1. Farrell, K., Auerbach, A., Liu, C., Martin, K., Pareno, M., Ray, W.K., Helm, R.F., Biase, F. & Jarome, T.J. (2023). Sex-differences in proteasome-dependent K48-polyubiquitin signaling in the amygdala are developmentally regulated. Biology of Sex Differences

  2. Swiley, C., Yu, L., Zheng, Y., Xu, H., Liu, M., Jarome, T.J., Hodes, G., & Xie, H. (2023). Sex linked behavioral and hippocampal transcriptomic changes in mice with cell-type specific Egr1 loss. Frontiers in Neuroscience, 1240209.

  3. Allen, L.M., Murphy, D.A., Moussa, M.N., Delgado, A., Jarome, T.J., Lee, K., Mattfield, A.T., Prather, R. & Allen, T.A. (2023). Spatial working memory testing in pigs using an automated TMaze. Oxford Open Neuroscience, kvad010.

  4. McFadden, T., Carcucci I., Farrell K., Fletchall E., & Jarome, T.J. (2023). Hypothalamic DNA 5- hydroxymethylation levels are altered by diet-induced weight gain during the development of obesity in a sex-specific manner. Brain Research, 1817, 148478.

  5. Patrick, M.B., Omar, N., Werner, C.T., Mitra, S.  Jarome, T.J. (2023). The ubiquitin-proteasome system and learning-dependent synaptic plasticity – a 10 year update. Neuroscience & BioBehavioral Reviews, 105280.

  6. Farrell, K., Musaus, M., Auerback, A., Navabpour, S., Ray, W.K., Helm, R.F. & Jarome, T.J. 2023). Lysine 63 polyubiquitination selectively regulates ATP synthesis and proteasome activity during fear memory formation in the female amygdala. Molecular Psychiatry

    *Altmetric score of 109. Featured on 13 news outlets.

  7. McFadden, T., Gaito, N., Carucci, I., Fletchall, E., Farrell, K. & Jarome, T.J. (2023). Controlling hypothalamic DNA methylation at the Pomc promoter does not regulate weight grain during the development of obesity. PLoS One, 18(4), e0284286Farrell, K.*, McFadden, T.* & Jarome, T.J. (2023). Neuronal and astrocytic protein degradation are critical for fear memory formation. Learning and Memory, 30, 1-4.

  8. Farrell, K.*, McFadden, T.* & Jarome, T.J. (2023). Neuronal and astrocytic protein degradation are critical for fear memory formation. Learning and Memory, 30, 1-4.

  9. Gollapudi, Y., Martin, K., Farrell, K. & Jarome, T.J. (2023). Sex differences in linear polyubiquitination in the entorhinal cortex during fear memory formation. Journal of Emerging Investigators, 6, 1-5.

  10. McFadden, T. Farrell, K., Martin, K., Musaus, M. & Jarome, T.J. (2023). Short-term exposure to an obesogenic diet causes dynamic dysregulation of proteasome-mediated protein degradation in the hypothalamus of female rats. Nutritional Neuroscience, 26, 290-302.

  11. Farrell, K., Auerbach, A., Musaus, M. & Jarome, T.J. (2022). The epigenetic role of proteasome subunit RPT6 during memory formation in females. Learning and Memory, 29, 256-264.

  12. Gustin, A., Navabpour, N., Farrell, K., Martin, K., DuVall, J., Ray, W.K., Helm, R.F. & Jarome, T.J. (2022). Protein SUMOylation is a sex-specific regulator of fear memory formation in the amygdala. Behavioural Brain Research, 430, 113928.

    *Selected as editors featured article for July 2022

  13. Maity, S.*, Farrell, K.*, Navabpour, S.*, Narayanan, S.N. & Jarome, T.J. (2021). Epigenetic mechanisms in memory and cognitive decline associated with aging and Alzheimer’s disease. International Journal of Molecular Science, 22, 12280Farrell, K.*, Musaus, M.*, Navabpour, S.*, Martin, K., Ray, W.K., Helm, R.F. & Jarome, T.J. (2021). Proteomic analysis reveals sex-specific protein degradation targets in the amygdala during fear memory formation. Frontiers in Molecular Neuroscience, 14, 716284

  14. Farrell, K.*, Musaus, M.*, Navabpour, S.*, Martin, K., Ray, W.K., Helm, R.F. & Jarome, T.J. (2021). Proteomic analysis reveals sex-specific protein degradation targets in the amygdala during fear memory formation. Frontiers in Molecular Neuroscience, 14, 716284

  15. Martin, K., Musaus, M., Navabpour, S., Gustin, A., Ray, W.K., Helm, R.F. & Jarome, T.J. (2021). Females, but not males, require protein degradation in the hippocampus for context fear memory formation. Learning and Memory, 28, 248-253.

  16. Musaus, M. Farrell, K., Navabpour, S., Ray, W.K., Helm, R.F. & Jarome, T.J. (2021). Sex-specific linear polyubiquitination is a critical regulator of contextual fear memory formation. Frontiers in Behavioral Neuroscience, 15, 709392.

  17. Jarome, T.J.* & Kwapis, J.L.* (2021). Special Issue: “Molecular Mechanisms of Memory Formation and Modification.” International Journal of Molecular Sciences, 22, 4113.

  18. Farrell, K. & Jarome, T.J. (2021). Is PROTAC technology really a game changer for central nervous system drug discovery? Expert Opinion on Drug Discovery, 1-8.

  19. Devulapalli, R.K.*, Jones, N.*, Farrell, K.*, Kugler, H., Musaus, M., McFadden, T., Orsi, S.A., Martin, K., Nelsen, J., Navabpour, S., O’Donnell, M., McCoig, E. & Jarome, T.J. (2021). Males and females differ in the engagement and regulation of, but not requirement for, protein degradation in the amygdala during fear memory formation. Neurobiology of Learning and Memory, 180, 107404.

  20. Jarome, T.J., Perez, G.A., Webb, W.M., Hatch, K.M., Navabpour, S., Musaus, M., Farrell, K., Hauser, R.M., McFadden, T., Martin, K., Butler, A.A., Wang, J. & Lubin, F.D. (2021). Ubiquitination of histone H2B by proteasomal RPT6 controls histone methylation chromatin dynamics during memory formation. Biological Psychiatry, 89, 1176-1187

  21. Navabpour, S., Roger, J., McFadden, T. & Jarome, T.J. (2020). DNA double-strand breaks are a critical regulator of fear memory reconsolidation. International Journal of Molecular Sciences, 21, 8995.

  22. Musaus, M.*, Navabpour, S.* & Jarome, T.J. (2020). The diversity of linkage-specific polyubiquitin chains and their role in synaptic plasticity and memory formation. Neurobiology of Learning and Memory, 174, 107286.

  23. McFadden, T., Musaus, M., Nelsen, J.L., Martin, K., Jones, N., Smith, P., Kugler, H. & Jarome, T.J. (2020). Dysregulation of protein degradation in the hippocampus is associated with impaired spatial memory during the development of obesity. Behavioural Brain Research, 393, 1-11.

  24. Navabpour, S., Kwapis, J.L.* & Jarome, T.J.* (2020). A neuroscientist’s guide to transgenic mice and other genetic tools. Neuroscience & Biobehavioral Reviews, 108, 732-748

  25. Devulapalli, R.K., Nelsen, J.L., Orsi, S.A., McFadden, T., Navabpour, S., Jones, N., Martin, K., O’Donnell, M., McCoig, E.L. & Jarome, T.J. (2019). Males and females differ in the subcellular and brain region dependent regulation of proteasome activity by CaMKII and Protein Kinase A. Neuroscience, 418, 1-14

  26. Butler, A.A., Sanchez, R.G., Jarome, T.J., Webb, W.M., & Lubin, F.D. (2019). O-GlcNAc and EZH2-mediated epigenetic regulation of gene expression during consolidation of fear memories. Learning and Memory, 26, 373-379

  27. McFadden, T., Devulapalli, R.K. & Jarome, T.J. (2019). Quantifying subcellular ubiquitin-proteasome activity in the rodent brain. Journal of Visualized Experiments, 147, e59695

  28. Ferrara, N.C.*, Jarome, T.J.*, Cullen, P.K., Orsi, S.A., Kwapis, J.L., Pullins, S.E. & Helmstetter, F.J. (2019). GluR2 endocytosis-dependent protein degradation in the amygdala mediates memory updating. Scientific Reports, 9, 5180

  29. Orsi, S.A., Devulapalli, R.K., Nelsen, J.L., McFadden, T., Surineni, R. & Jarome, T.J. (2019). Distinct subcellular changes in proteasome activity and linkage-specific protein polyubiquitination in the amygdala during the consolidation and reconsolidation of a fear memory. Neurobiology of Learning and Memory, 157, 1-11.

  30. Jarome, T.J., Devulapalli, R.K. (2018). The ubiquitin-proteasome system and memory: Moving beyond protein degradation. The Neuroscientist, 24, 639-651

  31. Jarome, T.J., Perez, G.A., Hauser, R.M., Hatch K.M. & Lubin, F.D. (2018). Ezh2 methyltransferase activity controls Pten expression and mTOR signaling during memory reconsolidation. Journal of Neuroscience, 38, 7635-7648

  32. Webb, W.M. Sanchez, R.G., Perez, G., Butler, A.A., Hauser, R.M., Rich, M.C., O’Bierne, A.L., Jarome, T.J. & Lubin, F.D. (2017). Dynamic association of epigenetic H3K4me3 and DNA 5hmc marks in the dorsal hippocampus and anterior cingulate cortex following reactivation of a fear memory. Neurobiology of Learning and Memory, 142, 66-78

  33. Kwapis, J.L., Jarome, T.J., Ferrara, N.C., & Helmstetter, F.J. (2017). Updating procedures can reorganize the neural circuit supporting a fear memory. Neuropsychopharmacology, 42(8), 1688-1697.

  34. Maity, S.*, Jarome, T.J.*, Blair, J., Lubin, F.D. & Nguyen P.V. (2016). Norepinephrine goes nuclear: Epigenetic modifications during long-lasting synaptic potentiation triggered by activation of noradrenergic receptors. Journal of Physiology, 594.4, 863-881.

  35. Jarome, T.J.*, Ferrara, N.C.*, Kwapis, J.L. & Helmstetter, F.J. (2016).  CaMKII regulates proteasome phosphorylation and activity and promotes memory destabilization following retrieval.  Neurobiology of Learning and Memory, 128, 103-109.

  36. Jarome, T.J.*, Ferrara, N.C.* Kwapis, J.L. & Helmstetter, F.J. (2015).  Contextual information drives the reconsolidation-dependent updating of retrieved fear memories.  Neuropsychopharmacology, 40, 3044-3052.

  37. Jarome, T.J., Butler, A.A., Nichols, J.N., Pacheco, N.L. & Lubin, F.D. (2015).  NF-kB mediates Gadd45b expression and DNA demethylation in the hippocampus during fear memory formation.  Frontiers in Molecular Neuroscience, 8:54, doi: 10.3389/fnmol.2015.00054

  38. Kwapis, J.L., Jarome, T.J., Lee, J.L., & Helmstetter, F.J. (2015). The retrosplenial cortex is involved in the formation of memory for context and trace fear conditioning. Neurobiology of Learning and Memory, 123, 110-116.

  39. Kwapis, J.L., Jarome, T.J., & Helmstetter, F.J. (2015). The role of the medial prefrontal cortex in trace fear extinction. Learning and Memory, 22, 39-46.

  40. Jarome, T.J., Thomas, J.S. & Lubin, F.D. (2014). The epigenetic basis of memory formation and storage. Progress in Molecular Biology and Translational Science, 128C, 1-27. [Book chapter]

  41. Jarome, T.J. & Lubin, F.D. (2014).  Epigenetic mechanisms of memory formation and reconsolidation.  Neurobiology of Learning and Memory, 115, 116-127. [Review]

  42. Jarome, T.J. & Helmstetter, F.J. (2014).  Protein degradation and protein synthesis in long-term memory formation.  Frontiers in Molecular Neuroscience, 7:61. [Review]

  43. Gupta-Agarwal, S., Jarome, T.J., Fernandez, J. & Lubin, F.D. (2014).  NMDA receptor- and ERK-dependent histone methylation changes in the lateral amygdala bidirectionally regulate fear memory formation.  Learning and Memory, 21, 351-362.

  44. Kwapis, J.L., Jarome, T.J., Lee, J.L., Gilmartin, M.R. & Helmstetter, F.J. (2014).  Extinguishing trace fear engages the retrosplenial cortex rather than the amygdala.  Neurobiology of Learning and Memory, 113, 41-54.

  45. Jarome, T.J., Kwapis, J.L., Hallengren, J.J., Wilson, S.M. & Helmstetter, F.J. (2014).  The ubiquitin-specific protease 14 (USP14) is a critical regulator of long-term memory formation.  Learning and Memory, 21, 9-13.

  46. Reis, D.S., Jarome, T.J. & Helmstetter, F.J. (2013).  Memory formation for trace fear conditioning requires ubiquitin-proteasome mediated protein degradation in the prefrontal cortex.  Frontiers in Behavioral Neuroscience, 7:150.

  47. Jarome, T.J., Kwapis, J.L., Ruenzel, W.L. & Helmstetter, F.J. (2013).  CaMKII, but not Protein Kinase A, regulates Rpt6 phosphorylation and proteasome activity during long-term memory formation.  Frontiers in Behavioral Neuroscience, 7:115.

  48. Jarome, T.J. & Lubin, F.D. (2013).  Histone lysine methylation: Critical regulator of memory and behavior.  Reviews in the Neurosciences, 24, 375-387. [Review]

  49. Jarome, T.J. & Helmstetter, F.J. (2013).  The ubiquitin-proteasome system as a critical regulator of synaptic plasticity and long-term memory formation.  Neurobiology of Learning and Memory, 105, 107-116. [Review]

  50. Kwapis,J.L., Jarome, T.J., Gilmartin, M.R. & Helmstetter, F.J. (2012).  Intra-amygdala infusion of the protein kinase Mzeta inhibitor ZIP disrupts context fear memory.  Neurobiology of Learning and Memory, 98(2), 148-153.

  51. Jarome, T.J., Kwapis, J.L., Werner, C.T., Parsons, R.G., Gafford, G.M. & Helmstetter, F.J. (2012). The timing of multiple retrieval events can alter GluR1 phosphorylation and the requirement for protein synthesis in fear memory reconsolidation.  Learning and Memory, 19(7), 300-306.

  52. Kwapis, J.L., Jarome, T.J., Schiff, J. & Helmstetter, F.J. (2011).  Memory consolidation in both trace and delay fear conditioning is disrupted by intra-amygdala infusion of the protein synthesis inhibitor anisomycin.  Learning and Memory, 18, 728-732.

  53.  Jarome, T.J., Werner, C.T., Kwapis, J.L. & Helmstetter, F.J. (2011). Activity dependent protein degradation is critical for the formation and stability of fear memory in the amygdala.  PLoS One, 6(9), e24349. DOI: 10.1371/journal.pone.0024349.

  54.  Lonergan, M.E., Gafford, G.M., Jarome, T.J. & Helmstetter, F.J. (2010). Time-dependent expression of Arc and zif268 after acquisition of fear conditioning. Neural Plasticity, e139891. DOI: 10.1155/2010/139891

  55. Jarome, T.J., Kwapis, J.L., Nye, S.N. & Helmstetter, F.J. (2010). Introgression of Brown Norway chromosome 1 onto Fawn Hooded Hypertensive background rescues long-term fear memory deficits. Behavior Genetics, 40(1), 85-92.

    2009

  56. Lee, T., Jarome, T., Li, S-J., Kim, J.J. & Helmstetter, F.J. (2009). Chronic stress selectively reduces hippocampal volume in rats: a longitudinal MRI study. Neuroreport, 20, 1554-1558.

  57.  Kwapis, J.L., Jarome, T.J., Lonergan, M.E. & Helmstetter, F.J. (2009). Inhibition of protein kinase Mz erases an established fear memory in the amygdala but not the hippocampus. Behavioral Neuroscience, 123(4), 844-850.